大會邀請8月28日擔任座長。當日另有海報發表。 一、錄取之Abstract The therapeutic effect of hyaluronic acid (HA) bladder instillation in patients with Interstitial Cystitis / Bladder Pain Syndrome (IC/BPS) Ming-Huei Lee1,2, Wei-Chih Chen1, Huei-Ching Wu1,2, Sheng-Pien Lee1, Wen-bin Liu1, Hsiu-Ming Lin1 1 Department of Urology, Fong Yuan Hospital, Department of Health, Taiwan, 2Central Taiwan University of Science and Technology Purpose: Bladder epithelium is not only defence to infections but also a tissue with afferent and efferent function as release of mediator and playing an important role in the pathogenesis of lower urinary tract dysfunction (LUTD). IC/BPS is one of LUTD that can be pathophysiologically linked to defects in the glycosaminoglycan (GAG) mucosal layer. Recent studies supported that 65% of positive response rate after bladder instillation of HA was noted in IC/BPS patients but lack of control group and outcome parameters only subjective symptoms were included. The aim of this study was to compare efficacy with HA bladder instillation plus hydrodistension and only hydrodistension by using subjective symptom scores and urodynamic parameters. Materials and Methods: This is a prospective case control study. 64 patients (age 27-65 year-old) compatible with the NIDDK criteria and all patients were not previously treated for IC/BPS before hydrodistention were enrolled in this study. Among the patients, 32 patients were assigned to receive hydrodistension and four times weekly plus two tomes monthly bladder instillation of 40mg HA (HA group) and other 32 patients were assigned to receive hydrodistension only as control group. Validated questionnaire including O'Leary-Sant Symptom (ICSI) and Problem Index (ICPI), bladder pain visual analogue scale (VAS), bladder urgency score, and Global response assessment (GRA) were collected at 4th month, 6th month, and baseline as before therapy. Urodynamic examination was also performed at baseline and 4th month. Results: Patient demographics showed no difference between two groups. Highly significant improvement of ICSI/ICPI, PUF, VAS, urgency score, and GRA was observed at 4th month compare to control group respectively (6.9 v 10.2, 4.7 v 9.2, 11.3 v 15.5, 3.2 v 4.4, 3.4 v 5.5, 57.8% v 45.3%, p<0.05). The trend was also observed significantly compare to control group at 6th month except VAS. The change from baseline to 4th month and 6th month showed significant improvement including all subjective symptom score in HA group (p<0.001). However, there was no difference between 4th month, 6th month and baseline in control group. The change of urodynamic parameter including maximum flow rate (Qmax), the volume of first desire to void (FDV), and maximum cystometric capacity (MCC) showed no significant difference from baseline to 4th month. Finally, no serious adverse events were recorded in this study except urinary tract infection (UTI). Conclusions: The use of hydrodistension plus HA instillation provided effect in reducing subjective symptoms but not objective urodynamic parameters in IC/BPS patients compare to hydrodistension only . However, bladder pain syndrome was relapse first in our follow-up at 6th month. The improvement of pain was difficult to complete by using HA instillation plus hydrodistension due to multi-pathogenesis of IC/BPS. 二、大會議程 三、錄取海報 四、大會參加證